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Specialty Services

Renal Pathology

Renal Pathology is a unit of the Histopathology Section.

Renal biopsy is done to identify diseases involving the kidneys. This procedure will guide the clinician in the treatment and prognosis of the disease.

Renal diseases are diagnosed using the 3 microscopy techniques namely: Light Microscopy (LM), Immunofluorescence Microscopy (IMF) and Electron Microscopy (EM).

Renal Pathology offers 5 stains for light microscopy. These are the Hematoxylin and Eosin Stain (H&E), Masson Trichrome Stain (MTS), Periodic Acid Stain (PAS), Periodic Acid Silver Stain (PAAg) and Periodic Silver Masson Trichrome Stain (PGMT).

Congo Red Stain for amyloid is also available.

Five (5) antibodies are used for the immunofluorescence microscopy. These are IgG, IgA, IgM, C3, C1q and fibrinogen.

Electron Microscopy (EM) is used to localize and characterize the electron dense deposits thus confirming the immunofluorescence findings. This is also used to identify abnormalities in the glomerular basement membrane and other structures not usually seen in the light microscope.

Other procedures which identify causes of renal allograft dysfunction are also being offered.

C4d (immunofluorescence and immunoperoxidase)oxidase) - a widely accepted marker for acute humoral rejection (AHR)
CD3 - pan-T cell marker used to identify T lymphocytes responsible for acute rejection
CD8 - for identification of cytotoxic T cells (T-killer cells)
CD68 - for identification of macrophages
SV40 - for identification of epithelial cells infected by the polyomavirus (BK virus)
Urine Decoy Cells - a screening test for the presence of BK virus in the urinary tract

    Packages, priced lower than the sum of the individual procedures if requested separately, are available upon request.

National Kidney and Transplant Institute, East Avenue Quezon City Philippines 1100